Biochemical markers in saliva of patients with oral squamous cell carcinoma

Saliva as a biological fluid has growing interest as a diagnostic tool over the past decade. Saliva contain a wide spectrum of proteins/peptides, nucleic acids, electrolytes, and hormones that originate from multiple local and systemic sources. In our earlier investigation some of salivary biomarkers in oral cancer patients found to have significant correlation with pathogenesis of oral squamous cell carcinoma (OSCC)[1]. Even though saliva consider as a reflection of body’s health but limitation of using saliva as a diagnostic tool is because of lack of information regarding the biomarker’s present in saliva and their correlation with disease etiology and above all the absence of highsensetive method for detection of these biomarkers. Diurnal/ circadian variations of some biomarkers available in saliva and not being the actual reflection of concentration in serum is consider to be disadvantage of using saliva as a diagnostic medium. Method implied for collection and degree of stimulation affect the composition of saliva[2,3]. Concentration of some of the biomarkers in saliva are 300 to 3 000-fold less than those in blood[4]. Accurate and sensitive PEER REVIEW ABSTRACT